The status of the coronary collaterals has also been shown to be influenced by the presence of diabetes mellitus. Coronary collateralization exists latently in the normal heart. Collateral vessels benefit some myocardial ischemia patients when their extra vessels open up and supply blood to the heart, partially replacing the lack of circulation in the blocked arteries… Collateral blood vessels are small capillary-like branches of an artery that form over time in response to narrowed coronary arteries. Microscopic collateral vessels of the heart undergo a process called transformation that widens the vessel lumen at the expense of its cell wall in response to myocardial stresses—specifically, myocardial spasm and hypoxia secondary to myocardial infarction or acutely stressful exercise.


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